Engineering Biological Systems with Synthetic RNA Molecules
نویسندگان
چکیده
منابع مشابه
Synthetic Biology: Engineering Biological Systems
On June 26, 2000, President Bill Clinton and Prime Minister Tony Blair, along with Francis Collins, director of the Human Genome Project at the NIH, and Craig Venter, president of Celera Genomics, announced the arrival of the genomic era with the sequencing of the first draft sequence of the human genome. With this wealth of information, scientists and policy-makers alike were eager to welcome ...
متن کاملPAMAM dendrimers interact with biological RNA molecules
Polycationic dendrimer-based gene transfer is one of the most important biological applications of dendrimers, which involves electrostatic interactions between the positively charged dendrimer end groups and the negatively charged phosphate groups in DNA. Such features could also be used to bind biologically important RNA molecules, which are emerging as both important therapeutic targets and ...
متن کاملEngineering Complex Synthetic Transcriptional Programs with CRISPR RNA Scaffolds
Eukaryotic cells execute complex transcriptional programs in which specific loci throughout the genome are regulated in distinct ways by targeted regulatory assemblies. We have applied this principle to generate synthetic CRISPR-based transcriptional programs in yeast and human cells. By extending guide RNAs to include effector protein recruitment sites, we construct modular scaffold RNAs that ...
متن کاملEngineering scalable biological systems.
Synthetic biology is focused on engineering biological organisms to study natural systems and to provide new solutions for pressing medical, industrial and environmental problems. At the core of engineered organisms are synthetic biological circuits that execute the tasks of sensing inputs, processing logic and performing output functions. In the last decade, significant progress has been made ...
متن کاملInformative Molecules in Biological Systems
and facilities. A book whichl describes clinical chemistry teclhniques should pro-vi(le sufficient discussion of theory and principles to give the readcer enoughi back-grounld wisely to select and evaluate metlhods and to remain current in tlle field. NILucII of Tcchniquics of Clinical Chlmistry lhas the format of a recipe book. No explaniation of the autlhors rationale for choice of methods is...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Cell
سال: 2011
ISSN: 1097-2765
DOI: 10.1016/j.molcel.2011.08.023